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Covid-19 Associated Thromboembolic Events And Mortality In Hospitalized Patients - A Uc Covid Research Data Set (cords) Retrospective Analysis
Dalia Breziner, B.A., Brian Tran, B.S., PhD, Anthony Chau, M.D..
UCI School of Medicine, Irvine, CA, USA.

OBJECTIVES: Differing rates of deep vein thrombosis (DVT) and pulmonary embolism (PE) have been reported following COVID-19 infection. We aim to assess the occurrence and outcomes of thromboembolic events (TE) and mortality in hospitalized patients with COVID-19.
METHODS: We performed a retrospective cohort analysis using the University of California COVID Research Data Set (UC CORDS), an electronic health record data warehouse consisting of patient data from five UC medical centers. We identify hospitalized patients who had a primary or secondary diagnosis of COVID-19 from July 31, 2021 until October 15, 2022. Statistical analyses were performed using one-way ANOVA and simple T-Tests.
RESULTS: 11,856 patients were admitted with COVID-19. 5323 were female (44.89%) and 6533 were male (55.11%). The mean age was 57 years. The overall incidence of TE was 7.29% (n= 864). The incidence of DVT, PE and those with DVT and PE were 3.18%, 3.09% and 1.02% respectively. Male gender had higher rates of TE compared to female gender (OR=1.4, CI = 1.2- 1.6, p <0.01). TE were associated with increased age (mean 61.87 years), respiratory disorders, pulmonary hypertension (pulm HTN), ischemic heart disease (IHD), obesity and acute respiratory distress syndrome (ARDS) (p < 0.001). The overall mortality rate was 10.12%. Male gender had a higher risk of mortality (OR=1.45, CI = 1.3-1.7, p <0.01). Older age, hypertension, hyperlipidemia, diabetes, pulmonary HTN, respiratory disorders, IHD, and ARDS were associated with increased mortality (p < 0.001). Race/Ethnicity was not a predictor for TE nor mortality.
CONCLUSIONS: COVID-19 associated thromboembolic events and mortality are high in hospitalized patients. Risk factors associated with higher occurrence include age, male gender, metabolic syndrome, respiratory disorders, ischemic heart disease and ARDS.
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