Mortality In Coronavirus 2019 (covid-19) Patients With Risk Factors For Atherosclerosis
Nicole Ilonzo, Ajit Rao, Christopher Faries, Anthony Turner, Sung Yup Kim, Ageliki Vouyouka, Rami Tadros, Windsor Ting, Soma Brahmanandam, Michael Marin, Peter Faries.
Mount Sinai Hospital, New York, NY, USA.
OBJECTIVES: The primary objective of this study is to assess how risk factors for atherosclerosis predict worse outcome following coronavirus 2019 (COVID-19) infection.
METHODS: Data for 9,530 patients with laboratory confirmed COVID-19 disease was assessed utilizing the Mount Sinai Health System deidentified database. Univariate analysis including chisquare and student t-test was utilized to analyze demographics and comorbidities between expired and alive patients. The primary outcome was mortality, which was analyzed using chisquare analysis. Multivariate stepwise logistic regression was used to evaluate risk factors associated with mortality. All statistical analyses were performed on SAS 9.4 (SAS Institute, Cary, NC).
RESULTS: Of the 9,530 patients with laboratory confirmed COVID-19 disease, the majority of patients (75.28%) had at least one risk factor for atherosclerosis, including hypertension (26.57%), diabetes mellitus (16.92%), obesity (7.18%), and COPD (2.78%). More patients with risk factors for atherosclerosis were intubated than patients without risk factors (10.17 vs. 1.88%, p<.001). The mortality rate was 18.34% in patients with 1 risk factor or more and 1.53% in patients with no risk factors, p<.05. The likelihood of mortality in a patient with any atherosclerosis risk factor was 12.76 times greater than patient without risk factors on multivariate analysis. The mortality rate increased with age; for every decade after the forties, mortality went up by 10.56% per decade.
CONCLUSIONS: This study reveals that risk factors for atherosclerosis, especially age and hypertension, result in increased severity of COVID disease as evidenced by increased rates of intubation and increased mortality. More patients with risk factors of atherosclerosis were admitted to the critical care unit, and length of stay was significantly longer in these patients.
Back to 2021 Karmody Posters