Back to 2025 Display Posters
Impact Of GNRI On Lower Extremity Revascularization Outcomes In Peripheral Artery Disease: A Systematic Review
Abdul Wasay A. Paracha, B.S., Ahsan Zil-E-Ali, M.B.B.S, Alpha Tall, B.S, Andrea Shehaj, B.S, Brian Chilin, B.S, Faisal Aziz, M.D.
Penn State College of Medicine, Hershey, PA, USA.
OBJECTIVES: Nutritional status is a well-known risk factor that can impact surgical outcomes. Many studies have assessed the nutritional status by using various indexes, like Geriatric Nutritional Risk Index (GNRI), and analyzed its impact on post-operative outcomes. This systematic review aims to assess the correlation between GNRI scores and surgical outcomes in patients undergoing lower extremity revascularization (LER) for Peripheral Artery Disease (PAD).
METHODS: A systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. After the collection and analysis of all included studies, the risk of bias was investigated by using the Risk of Bias in Non-randomized Studies of Interventions (ROBINS-I) tool.
RESULTS: A total of 345 papers were screened after duplicate removal. 15 studies met the inclusion criteria and were assessed for the relationship between GNRI scores and post-operative outcomes after LER for PAD. The results of these studies showed an association between poor nutritional status, as indicated by low GNRI scores, with poor surgical outcomes. Some of the key findings were higher mortality rates and increased major amputation rates among patients with low GNRI scores. This could Indicate that the severity of PAD is exacerbated in patients with poor nutritional status, potentially limiting their post-operative recovery. Additionally, patients with low GNRI scores had decreased amputation free survival, highlighting the importance of pre-operative nutritional assessment in managing PAD patients. Finally, the risk of bias assessment revealed an overall moderate bias between all the studies.
CONCLUSIONS: Low GNRI scores are associated with poor outcomes following LER surgery. Risk stratification should be done using nutritional indexes, like GNRI scores, in patients undergoing these procedures. Addressing the nutritional status can be beneficial in limiting long-term complications in these patients.
Back to 2025 Display Posters
